I can't speak for others, but for my position, there really wasn't much in the way of work/life balance. Ultimately that's why I decided to leave. But retrospectively, I think it was only this way because I was so committed to Riot's mission that I gave too much of myself to it. Riot do their best (within reason) to get you to your important family events, soccer games, church, whatever, but sometimes the nature of the job just doesn't allow for it.
The training could be better. I came in with a bit of a lopsided statsheet, and it took me ages to get up to scratch with the other aspects of the job that I wasn't experienced in. It was partly on me because I didn't ask for enough help, but I still feel that I was underequipped for my first few months.
It can be frustrating working for a regional office like Sydney, too. You join Riot wanting to be a hero for the players, but once you learn about and understand all the things that are holding Riot back from getting stuff out the door, you feel awful whenever you see a player asking for something that you personally can't deliver on (without sacrificing your personal time).